Parathyroid hormone related peptides affect diabetic osteoporotic fracture
10.3969/j.issn.2095-4344.2014.15.024
- VernacularTitle:甲状旁腺激素相关肽与糖尿病性骨质疏松性骨折：你知道哪些？
- Author:
Anlong LIU
;
Yong QIU
;
Yinhe WANG
- Publication Type:Journal Article
- Keywords:
parathyroid hormone;
diabetes mel itus;
osteoporosis;
osteoporotic fractures
- From:
Chinese Journal of Tissue Engineering Research
2014;(15):2442-2449
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Parathyroid hormone related peptides are accompanied by the syndrome of humoral hypercalcemia of malignancy. As a potential therapeutic drug of promoting the healing of bone fracture, parathyroid hormone related peptides have significant clinical application value.
OBJECTIVE:To explore the regulating effects of parathyroid hormone related peptides in diabetic osteoporotic fracture
METHODS:A computer-based online research of CNKI and PubMed databases was performed to col ect articles published between 1990 and 2013, with the key words“parathyroid hormone related peptides, diabetes, osteoporotic fracture”in Chinese and English. There were 1 279 articles after the initial survey. A total of 43 articles were included according inclusion and exclusion criteria.
RESULTS AND CONCLUSION:Animal and clinical experiments demonstrated that parathyroid hormone related peptides notably accelerate bone fracture healing, and improve the repair process of islet cellfunction defects that are related with diabetes. Meanwhile, as an analogue, parathyroid hormone has been identified as clinical medication in the treatment of fracture. But the appropriate dose, and method of application at the different stages of bone fracture healing and the problem of drug combination need further investigation.
