Mechanisms and challenges in joint application of radiotherapy and cancer immunotherapy
10.3969/j.issn.1000-8179.20140527
- VernacularTitle:放疗与免疫治疗联合应用的相关机制及研究进展
- Author:
Jinming YU
;
Feifei TENG
- Publication Type:Journal Article
- Keywords:
tumor;
radiotherapy;
immunotherapy
- From:
Chinese Journal of Clinical Oncology
2014;(9):547-550
- CountryChina
- Language:Chinese
-
Abstract:
The effects of radiotherapy (RT) on the survival of cancer patients are interpreted as a consequence of the improved lo-cal control of tumors that directly decrease systemic spreading. Some of the effects of ionizing radiation are recognized as a contribu-tion to systemic antitumor immunity, which can provide sufficient evidence for proposing a paradigm shift. Recent examples of objec-tive responses achieved by adding radiotherapy to immunotherapy in metastatic cancer patients support this view. Preclinical data indi-cate that RT can convert irradiated tumor into an in situ individualized vaccine and potentiate the systemic efficacy of immunotherapy, whereas activation of the innate and adaptive immune system can enhance the local efficacy of RT. This study summarizes key evi-dence that support the role of radiotherapy as an immune adjuvant and some of the current challenges in translating this knowledge for clinical use.
