Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases.
- Author:
Aran MIN
1
;
Daeho KIM
Author Information
1. Department of Psychiatry, Hanyang University Medical Center, Hanyang University School of Medicine, Seoul, Korea. dkim9289@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Blonanserin;
Bipolar disorder;
Antipsychotic agents;
Schizophrenia;
Psychotic disorders
- MeSH:
Antipsychotic Agents;
Bipolar Disorder;
Humans;
Outpatients;
Psychotic Disorders*;
Schizophrenia*;
Serotonin
- From:Clinical Psychopharmacology and Neuroscience
2013;11(3):165-167
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is a novel antipsychotic that acts as a 5-HT and D2 receptor antagonist. Both patients developed hypomanic episodes within 2 weeks of receiving a small dose (6-8 mg) of blonanserin, and one patient later developed full-blown mania; both episodes ended within 1 month of discontinuing blonanserin. The mood alteration observed in these cases suggests a possible antidepressant effect of blonanserin; thus, clinicians should monitor mood changes when administering this antipsychotic.
