Expression and clinical significance of IL-23 and IL-17 in patients with colorectal cancer
10.3969/j.issn.1000-8179.20132006
- VernacularTitle:IL-23和IL-17在结直肠癌患者中的表达及意义
- Author:
Jiansheng WANG
;
Yuanpeng LV
;
Juntao MENG
;
Jinxiao SONG
;
Lizhi ZHANG
;
Yanqing TIE
- Publication Type:Journal Article
- Keywords:
colorectal neoplasm;
IL-23;
IL-17
- From:
Chinese Journal of Clinical Oncology
2014;(9):580-584
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study was conducted to investigate the levels of IL-23 and IL-17 in sera and tumor tissues and to ana-lyze their association with clinico-pathological parameters in patients with colorectal cancer (CRC). Methods:A total of 24 healthy sub-jects and 56 patients with CRC were recruited in this study. Enzyme-linked immunosorbent assay was performed to measure the concen-trations of IL-23 and IL-17 in the sera of CRC patients and healthy controls and in cultured normal tissues and tumor tissues from CRC patients. Results:The levels of serum IL-23 and IL-17 were significantly higher in CRC patients than in healthy controls (P<0.01). The supernatant levels of IL-23 and IL-17 in tumor tissues were significantly higher than in normal tissues (P<0.05). Serum IL-17 level was correlated with tumor location, lymph node metastasis, and TNM stage (P<0.05), whereas serum IL-23 level showed no correlation with all clinico-pathological parameters (P>0.05). Tumor supernatant IL-17 level was correlated with tumor differentiation, lymph node metastasis, and TNM stage (P<0.05), whereas tumor supernatant IL-23 level was correlated only with TNM stage (P<0.05). Conclu-sion:IL-23 and IL-17 may be involved in the immuno-pathogenesis of CRC progression.
