Polymorphisms in HIF1A gene are associated with prognosis of hepatocelluar carcinoma
10.3969/j.issn.1002-1671.2014.05.029
- VernacularTitle:HIF1A 基因多态性与原发性肝癌预后相关性研究
- Author:
Kan WANG
;
Shen WANG
;
Xiaohe YU
;
Zhiyong SHI
;
Ping QU
;
Xiaojun HUANG
;
Yefa YANG
;
Hongxin ZHANG
- Publication Type:Journal Article
- Keywords:
advanced hepatocelluar carcinoma;
transarterial chemoembolisation;
hypoxia-inducible factor-1αgene;
single nucleo-tide polymorphism
- From:
Journal of Practical Radiology
2014;(5):830-833
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the association between polymorphisms in HIF1α gene and prognosis of advanced hepatocelluar carcinoma.Methods We collected prognosis data from a cohort of 448 advanced HCC patients treated by transarterial chemoembo-lisation,and used 5ml peripheral blood from patients for extraction DNA.Three SNPs (rs2301 1 13、rs2057482 and rs1 957757 )in HIF1αgene were selected and genotyped.Multivariate Cox proportional hazards model,Kaplan-Meier curve and log-rank test were used for prognosis analyses.Results The variant-containing genotypes (WV+VV)of SNP rs2301 1 13 exhibited a significant associ-ation with a better overall survival in HCC patients who had tumor size smaller than 5 cm (hazard ratio [HR],0.58,95% confidence interval [CI],0.35-0.96,P =0.036).In the patients taken single tumor subgroup,the variant-containing genotypes (WV+VV) of SNP rs2301 1 13 exhibited a significant association with a better overall survival (log-rank P =0.048),comparing to those carrying wild-type genotype.Conclusion Our results suggest that polymorphisms in HIF1αgene may serve as an independent prognosis bio-marker for advanced HCC patient.
