Preliminary discussion on the effects of guanosine, curcumin on learning and memory in AD double transgenic mice
10.3969/j.issn.1005-4847.2014.02.007
- VernacularTitle:初步探讨鸟嘌呤核苷、姜黄素对 AD 双转基因小鼠学习记忆的影响
- Author:
Hui FAN
;
Huili FENG
;
Huizi DANG
;
Xiaopei CHEN
;
Ying REN
;
Jinduo YANG
;
Pengwen WANG
- Publication Type:Journal Article
- Keywords:
Guanosine;
Curcumin;
APPswe/PS1dE9 double transgenic mice;
Ethology
- From:
Acta Laboratorium Animalis Scientia Sinica
2014;(2):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective Using Morris water maze test to evaluate the effects of guanosine and curcumin on cognitive function of APPswe/PS1dE9 double transgenic mice .Methods 3-month old APPswe/PS1dE9 dtg mice were randomly di-vided into model group , donepezil HCL group , guanosine group , curcumin group , curcumin and guanosine group ( n=12), with age-matched Wild C57BL/6J mice of the same genetic background as normal control group .Medication was giv-en once a day for 1 month.Using Morris water maze to test the spatial learning and memory ability of mice .Results Guanosine and curcumin could improve spatial learning and memory disorders of AD mice , particularly in the group of cur-cumin.Conclusion Guanosine and curcumin improve the cognitive ability of APPswe /PS1dE9 double transgenic mice with early cognitive impairment .
