Histological changes of the right ventricular remodeling in Xinjiang Marmota baibacina adapted to high-altitude hypoxia
10.3969/j.issn.1005-4847.2014.02.010
- VernacularTitle:高原低氧适应动物新疆灰旱獭右心室重构的组织学改变
- Author:
Mei MA
;
Tao JIANG
;
Chun ZHANG
;
Qin WEI
;
Minjun DUAN
;
Xuemei WANG
;
Zhiqiang LI
;
Xi SHOU
;
Qilong CHEN
- Publication Type:Journal Article
- Keywords:
High-altitude hypoxia;
Right ventricular remodeling;
Xinjiang Marmota baibacina
- From:
Acta Laboratorium Animalis Scientia Sinica
2014;(2):45-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the histological changes of the right ventricular remodeling in Xinjiang Mar-mota baibacina which are adapted to high-altitude hypoxia .Methods Hematoxylin and eosin and Masson staining was used to examine the pathological changes and degree of fibrosis , and immunohistochemical technique was used to detect connexin 43 ( CX43) expression in the right ventricular myocardium .Results In the right ventricular myocardium , cardio-myocyte hypertrophy and increased amount of collagen fibers were observed .The right ventricular hypertrophy index and weight index of Marmota baibacina were significantly higher , and expression of CX43 was significantly reduced than that of normal rats ( P<0.05 for both ) .Conclusions High-altitude hypoxia induces right ventricular remodeling in Xinjiang Marmota baibacina.It can be used as an ideal animal model for studies on the mechanisms of hypoxia adaptation on high -altitude plateau .
