The potential value of microRNA in the development of tuberculosis and its early diagnosis
10.3760/cma.j.issn.1009-9158.2014.05.004
- VernacularTitle:微小 RNA 对结核病发生发展及早期诊断的潜在价值
- Author:
Ming CHEN
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
MicroRNAs;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2014;(5):330-333
- CountryChina
- Language:Chinese
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Abstract:
Tuberculosis a disease with the highest death rate by single pathogenic infection can cause serious harm to human health .MicroRNA ( miRNA ) is a classical single-stranded, short RNA molecules ( about 21 to 25 nucleotides ) that plays an important role in cell proliferation , differentiation , senescence and apoptosis by inhibiting the post-transcriptional gene expression or promoting degradation of target gene mRNA . Recent studies have shown that miRNA involved in the regulation of apoptosis , expression of pro-inflammatory cytokines , inflammation-related signaling pathways in tuberculosis infection . Meanwhile, miRNA may be a new biomarker for tuberculosis diagnosis.
