Research on antibacterial property of snake venom antibacterial peptide OH-CATH and chitosan as artificial implant coating
10.3969/j.issn.1671-8348.2014.11.003
- VernacularTitle:蛇毒抗菌肽OH-CATH和壳聚糖作为人工植入物涂层的抗菌性研究
- Author:
Siman LI
;
Guoyu YU
;
Guomin ZHAI
;
Zhenhua GAO
;
Jihong SHEN
;
Yancheng PENG
- Publication Type:Journal Article
- Keywords:
snake venom;
antibiotic peptide;
OH-CATH;
chitosan;
escherichia coli;
prostheses and implants
- From:
Chongqing Medicine
2014;(11):1287-1289
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the bacteriostatic efficacy of snake venom antibacterial peptide OH-CATH and chitosan as ar-tificial implant coating on escherichia coli (E .coli) .Methods The catheters and dacron patches (blank group ,chitosan group ,cef-operazone group and antibacterial peptide group) were performed the pretreatment .Then the in vitro bacteriostatic test was conduc-ted to evaluate the antibacterial activity U value on E .coli ATCC 25922 and cephalosporin-resistant E .coli on 1 d and on 7 d after putting it into plasma .Results The cefoperazone group and the antibiotic peptide group had the very powerful antibacterial activity on E .coli ATCC 25922 on 1 ,7 d ,but the antibacterial activity of the cefoperazone group was stronger than that of the antibiotic peptide group(P<0 .05);the cefoperazone group had no antibacterial activity on cephalosporin-resistant E .coli ,but the antibiotic peptide group had significantly antibacterial activity on 1 ,7 d(P<0 .01) .Conclusion Snake venom antibacterial peptide OH-CATH has very obvious antibacterial effect on the standard strain and drug-resistant strain of E .coli and its value applied in artificial im-plant coating is affirmed .
