Utility of the combination of fluorescence in situ hybridization with nuclear matrix protein 22 in the diagno-sis of bladder cancer
10.3969/j.issn.1006-5725.2014.07.020
- VernacularTitle:荧光原位杂交和核基质蛋白22联合检测在膀胱癌诊断中的应用
- Author:
Junwu RAN
;
Jun LV
;
Wei WANG
;
Maguang LU
;
Xiaodong CHEN
;
Xiaodong HUANG
;
Weilie HU
- Publication Type:Journal Article
- Keywords:
Fluorescence in situ hybridization;
Nuclear matrix protein 22;
Bladder cancer
- From:
The Journal of Practical Medicine
2014;(7):1073-1076
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate a non-invative , sensitive and specific method to diagnose bladder cancer, and evaluate the value of the combination of FISH with NMP22 in the diagnosis of bladder cancer. Methods Urine from 68 patients suspected suffering from bladder cancer were used by FISH, NMP22 expression and cytologi-cal examination, respectively. The results of above detections were compared to the subsequent histopathology as-say to analyze the specicficity, sensitivity of diagnosis for bladder cancer. Results The sensitivity of FISH, NMP22 expression and the cytological examination was 81.4%,86.0% and 39.5% respectively, and the specifici-ty of FISH, NMP22 expression and the cytological examination was 84.0%, 72.0% and 96.0%, respectively. The sensitivity and specificity of the combination of FISH with NMP22 was 79.1% and 92.0%. Conclusions The combined diagnosis of FISH and NMP22 for bladder cancer showed greater sensitivity than that of the conventional cytology, with similar specificity as the conventional cytology. The combination of FISH with NMP22 test shows more value for the diagnosis of bladder cancer than any single assay.
