Relationship between polymorphism of COX-2 and susceptibility of bladder cancer
10.3969/j.issn.1006-5725.2014.07.021
- VernacularTitle:环氧化酶-2基因多态性与膀胱癌的易感性研究
- Author:
Qian QIN
;
Jian QIN
;
Xianzhong BAI
;
Qinggui MENG
;
Jiwen CHENG
;
Haoyuan LU
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
COX-2;
Gene polymorphism
- From:
The Journal of Practical Medicine
2014;(7):1076-1079
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of polymorphism of 8473 (T/C,rs5275) in the 3′-untranslated region of cyclooxygenase-2 (COX-2) gene with bladder cancer. Methods A case-control study on the relation between COX-2 polymorphism and bladder cancer was performed in this study. The Taqman SNP genotyping assay was used to study the COX-2 rs5275 polymorphism. Results The differences in allele or genotype distributions of COX-2 rs5275 between cases and controls (all P < 0.05) were significant. A significantly reduced risk was revealed in bladder cancer patients carrying the TC genotype (adjusted OR =0.178;95%CI:0.119 ~0.264),CC genotype (adjusted OR = 0.087; 95%CI:0.058 ~ 0.129) or (TC/CC) genotype (adjusted OR =0.122;95%CI:0.082~0.181) compared to the control group. Significant difference in genotype distribution of the COX-2 rs5275 site was found associated with sex and smoking (adjusted OR:2.125,0.476;95%CI:1.500 ~3.010,0.325 ~ 0.696);No corelation was found between genetype TT or TC/CC and the pathological features of bladder cancer (P>0.05). Conlusion The separate effect of rs5275 polymorphism of COX-2 is associated with the susceptibility of bladder cancer, the TC/CC genotypes may be a protective factor.
