Effect of 6% hydroxyethylstarch (130/0.4) on hemorheology in patients with acute myocardial infarction complicated by shock

VernacularTitle:6％羟乙基淀粉（130／0．4）对急性心肌梗死合并休克患者血液流变学的影响
Author: Yingqiang GUO ; Xuebing CHEN ; Wei WU
Publication Type:Journal Article
Keywords: Myocardial infarction; Shock; Hemorheology; Hydroxyethylstarch
From: The Journal of Practical Medicine 2014;(7):1144-1146
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of 6% hydroxyethylstarch (130/0.4) on hemorheology in patients with acute myocardial infarction (AMI) complicated by shock before and after early fluid resuscitation. Methods 72 AMI patients complicated by shock were randomly divided into two groups , namely groupⅠwith 6%hydroxyethylstarch (130/0.4) for early liquid resuscitation and group Ⅱwith balanced salt (1.86% sodium lactate solution and compound sodium chloride solution for a ratio of 1∶2 ) for liquid recovery; and another 36 subjects was assigned to normal control group (groupⅢ). The hemorheological indices were detected after admission and 2 to 3 hours after fluid resuscitation in groupsⅠandⅡ. Results After fluid resuscitation , high-and low-shear viscosity , red cell aggregation index, hematocrit, fibrinogen, and platelet aggregation rate decreased in groupⅠand groupⅡ, with significant statistical differences (P < 0.05 and P < 0.01). Conclusions 6% hydroxyethylstarch (130/0.4) can effectively improve abnormal hemorheology in patients with AMI complicated by shock.