Experimental comparison of the antitussive and expectorant effects of seven traditional Chinese medicine compounds in mice
10.3969/j.issn.1005-4847.2014.02.015
- VernacularTitle:七个中药复方对小鼠止咳化痰作用的对比实验
- Author:
Xiaoju ZHANG
;
Yuan WU
;
Chunyan JIANG
;
Chaoying ZHANG
;
Xincai LAN
- Publication Type:Journal Article
- Keywords:
Traditional Chinese medicine compound;
Antitussive and expectorant;
Ammonia induced cough mod-el;
Tracheal phenol red secretion method;
Mice
- From:
Acta Laboratorium Animalis Scientia Sinica
2014;(2):66-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to screen effective traditional Chinese medicine compounds to prevent and control porcine respiratory disease syndrome ( PRDC) , seven compound preparations of traditional Chinese medicine were tested and to analyze their antitussive and expectorant effects in mice .Methods Two hundred 6-week old ICR mice ( male∶fe-male=1∶1) were used in this study .Dextromethorphan and ammonium chloride were used as positive control drugs , and physiological saline was used as blank control .The antitussive and expectorant effects of the seven Chinese medicine com-pounds (groups 1, 2, 3, 4, 5, 6, 7) were observed by ammonia-induced cough model and tracheal phenol red secretion method in mice .Results The results showed that compounds 7 and 5 significantly prolonged the cough incubation period (P <0.05), and reduced the cough times within 5 min (P <0.05).Except for the group 4, tracheal phenol red excre-tion in the other groups was significantly lower than that of blank control group (P <0.05), and phenol red excretion in the mice of groups 7, 5 and ammonium chloride group was significantly lower than that in other treatment groups ( P <0.05).Conclusions The Chinese medicine compounds 5 and 7 show most evident expectorant effects , and worthy of fur-ther validation of them as a drug in the treatment of porcine respiratory disease syndrome .
