A case-control study on risk factors of primary hepatocellular cancer in Guizhou
10.3969/j.issn.1671-8348.2014.10.002
- VernacularTitle:贵州省原发性肝癌危险因素的病例对照研究
- Author:
Xueke ZHAO
;
Quan ZHANG
;
Shasha CHEN
;
Jiawu TAN
;
Wenzhi WANG
;
Mingliang CHENG
- Publication Type:Journal Article
- Keywords:
liver neoplasms;
case-control studies;
hepatitis B;
alcohol drinking
- From:
Chongqing Medicine
2014;(10):1157-1160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the common risk factors of primary hepatocellular cancer (PHC) in Guizhou province . Methods The group case-control study was adopted .The main related-factors of primary PHC in Guizhou provincial population and the relation between drinking combined hepatitis B viral infection with the PHC occurrence were analyzed by the unconditional Logistic regression analysis and the stratification analysis .Results Drinking(OR=2 .948 ,95% CI 2 .096-4 .146 ,P=0 .000) ,eco-nomic status 5 years ago(OR=0 .386 ,95% CI 0 .279 -0 .534 ,P= 0 .000) ,family history of PHC(OR= 2 .402 ,95% CI 1 .372 -4 .206 ,P=0 .002) ,cigarette smoking (OR=3 .468 ,95% CI 2 .265 -5 .311 ,P=0 .000) ,chronic liver disease(OR= 1 .502 ,95% CI 1 .054-2 .141 ,P=0 .024) ,HBV infection(OR=31 .999 ,95% CI 19 .318 -53 .002 ,P=0 .000) and diabetes mellitus(OR=4 .750 , 95% CI 2 .761-8 .171 ,P=0 .000) ,the differences between the patients group and the control group had statistical significance ;the OR value of drinking combined with HBV infection was 96 .903(95% CI 35 .265-266 .275 ,P=0 .000) .Conclusion HBV infection is still the common risk factor of PHC in Guizhou provincial population .Drinking can increase the risk in the individuals infected with HBV .
