Influence of trimetazidine hydrochloride on plasma brain natriuretic peptide and 6min walking distance ;in aged patients with chronic congestive heart failure
10.3969/j.issn.1008-0074.2014.02.18
- VernacularTitle:盐酸曲美他嗪对老年心衰患者血浆脑钠肽及6 min步行试验的影响
- Author:
Wei ZHANG
;
Yong SHENG
;
Xuechun SUN
;
Biao CHENG
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Natriuretic peptide,brain;
Exercise test;
Trimetazidine
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(2):179-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe influence of trimetazidine on cardiac function in patients With chronic heart failure (CHF).Methods:According to number table method,a total of 70 CHF patients accorded With inclusion standards Were randomly and equally divided into trimetazidine group and routine treatment group.According to patient's condition,routine treatment group received digitalis,diuretics,angiotensin converting enzyme inhibitors etc CHF routine freatment.Trimetazidine group additionally received trimetazidine based on routine treatment.The treat-ment period Was four Weeks.Plasma brain natriuretic peptide (BNP)level Was measured and patients received 6min Walking test (6MWT)before and after treatment.Results:Compared With before treatment,there Was significant decrease in plasma BNP level in tWo groups after treatment (P<0.01),compared With routine treatment group, there Was significant increase in decreasing amplitude of BNP level [(655.89±135.61)pg/ml vs.(715.60±181.22) pg/ml,P<0.05]in trimetazidine group;compared With before treatment,there Was significant increase in 6min Walking distance (6MWD)in tWo groups after treatment (P<0.01),compared With routine treatment group,there Was significant increase in increasing amplitude of 6MWD [(181.46±51.16)m vs.(226.06±65.18)m,P<0.01] in trimetazidine group.Conclusion:Treatment trimetazidine can significantly reduce plasma brain natriuretic peptide level and improve heart function based on routine treatment in patients With heart failure.
