Selection of surfactants and dissolution profiles of nimesulide sustained-release tablets
10.7644/j.issn.1674-9960.2014.03.009
- VernacularTitle:尼美舒利缓释片溶出介质筛选和释放机制的研究
- Author:
Shaolong HE
;
Chunsheng GAO
;
Xinyi CHANG
;
Yuli WANG
;
Li SHAN
;
Huijuan WANG
;
Meiyan YANG
- Publication Type:Journal Article
- Keywords:
nimesulide;
micelles;
poorly water-soluble drug;
surfactant;
equilibrium solubility;
in vitro release
- From:
Military Medical Sciences
2014;(3):198-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of surfactants on the dissolution profiles of poorly water-soluble acidic drug nimesulide from sustained-release tablets.Methods The anionic surfactant sodium dodecyl sulfate (SDS), cationic sur-factant cetyltrimethyl ammonium bromide (CTAB) and nonionic surfactant polysorbate 80 (Tween 80) were used to prepare nimesulide micelles .The effect of the buffer , surfactant and ionic strength on the equilibrium solubility of the drug and the in vitro release of sustained-release tablets was studied .Results and Conclusion In pH 1.2 HCl solution, water and pH 6.8 phosphate buffer, the solubilization capacity of CTAB was the highest.However, in pH 9.0 Tris buffer, when CTAB concen-tration was at about 1%, the equilibrium solubility of nimesulide was at the trough value .The in vitro release results were similar to those of equilibrium solubility and the kinetic pattern conformed to the first order equation according to the coefficient R .
