The clinical curative observation on the treatment of primary hepatic carcinoma by combined therapy of Fuyuan-Huoxue decoction and transcatheter hepatic arterial chemoembolization
10.3760/cma.j.issn.1673-4246.2014.05.011
- VernacularTitle:复元活血汤联合介入治疗原发性肝癌的疗效分析
- Author:
Zhenzhen CHU
;
Lihong CHEN
;
Zhuxiao HUANG
;
Zhijie LIN
;
Zhenhua HU
;
Ying YANG
;
Shushan YIN
;
Chong GAO
- Publication Type:Journal Article
- Keywords:
Primary hepatic carcinoma;
Fuyuan Huoxue decoction;
Transcatheter hepatic arterial chemoembolization;
Combined therapy of TCM and modern medicine
- From:
International Journal of Traditional Chinese Medicine
2014;(5):426-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effects of combined therapy of Fuyuan Huoxue decoction and transcatheter hepatic arterial chemoembolization in the treatment of primary hepatic carcinoma. Methods 80 patients with primary hepatic carcinoma were randomly divided into a control group, treated by transcatheter hepatic arterial chemoembolization, and a treatment group, additionally treated by Fuyuan Huoxue decoction on the basis of the control group. By observing the change of gross tumor volume、tumor markers、clinical symptoms、Karnofsky Performance Status(KPS) score、quality of life and so on,compare the clinical effects and quality of life between the two groups. Results The effective rate of solid tumor was 47.50%and 35%in the treatment and the control group respectively, with no significant difference(χ2=-1.229, P>0.05);The total effect rate was 87.50%and 32.50%in the treatment and the control group respectively, with significant difference(χ2=-5.633, P<0.05);The rate of patients merged with portal vein tumor thrombus whose cancer embolus narrowed more than 1/2 after the treatment was 78.95%and 33.33%in the treatment and the control group respectively, with significant difference(χ2=7.836, P<0.05);The rate of alpha fetoprotein(AFP) decreasing or turning negative was 78.95%and 37.83%after the treatment in the treatment and the control group respectively, with significant difference(χ2=-3.857, P<0.05);Both groups have improvement in Karnofsky Performance Status(KPS) score after the treatment, the ratios was 80% and 72.50% in the treatment and the control group respectively, with no significant difference(χ2=-1.203, P>0.05);The accumulated scores change of quality of life(QOL) has asignificant difference(χ2=-3.025, P<0.05) between the two groups after the treatment. Conclusion The combined therapy of Fuyuan Huoxue decoction and transcatheter hepatic arterial chemoembolization can alleviate the clinical symptoms, improve treatment effects and quality of life of patients with primary hepatic carcinoma.
