Clinicopathologic features and prognostic factors of papillary renal cell carcinoma
10.3969/j.issn.1007-3969.2014.04.010
- VernacularTitle:乳头状肾癌的临床病理特征及其预后因素
- Author:
Mingzhu GAO
;
Jinyou WANG
;
Hailiang ZHANG
;
Hongkai WANG
;
Dingwei YE
;
Shiling ZHANG
;
Bo DAI
;
Yao ZHU
;
Xiaojian QIN
;
Chaofu WANG
- Publication Type:Journal Article
- Keywords:
Renal tumor;
Papillary renal cell carcinoma;
Prognosis
- From:China Oncology
2014;(4):299-303
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Papillary renal cell carcinomas (PRCC) is relatively infrequent, and there are few related researches in China. This study aimed to summarize the clinical and pathological features of PRCC, and evaluate prognostic factors for patients treated with surgery.Methods:A total of 64 patients who under-went surgery for PRCC were retrospectively assessed. PRCC tissue slides from each patient were reviewed for type (ⅠorⅡ), grade, TNM stage, coagulative tumor necrosis and microvascular invasion. We estimated overall survival using the Kaplan-Meier method. Multivariate analysis was done according to the Cox proportional hazards model of factors statistically signiifcant on univariate analysis. Results:The incidence rate of ENE was 6.04%in RCC, the median age was 55 (range 22 to 78) years. The comparison of the 22 (534.4%) typeⅠPRCCs and 42 (65.6%) typeⅡPRCCs revealed that typeⅡtumors were associated with a greater stage and grade more often. The median follow-up was 46 months (range 19 to 133). Of the 64 patients, 14 died, (4.5%) with typeⅠand 13 (31.0%) with typeⅡtumors (P=0.018). The overall survival rate was 85.7%in typeⅠtumors and 55.8%in typeⅡtumors, respectively. Univariate analysis identiifed symptoms at presentation, tumor type, TNM stage and grade as prognostic factors. On multivariate analysis only metastatic RCC remained associated with decreased overall survival (HR:14.78, P=0.004). Conclusion:The per-centage of PRCC is lower and typeⅡPRCC is relatively common compared with foreign data. Metastasis at diagnosis is an independent predictive parameter of overall survival in Chinese patients with PRCC.
