Protective effect of hydrogen-rich saline on ischemia-reperfusion-induced liver injury in rats

VernacularTitle:氢生理盐水对大鼠肝脏缺血再灌注损伤的保护作用
Author: Baoshan LI ; Qu LIU ; Qiang LI
Publication Type:Journal Article
Keywords: Hydrogen-rich saline (HS); Ischemia-reperfusion (I/R); Oxidative injury
From: Chinese Journal of Hepatobiliary Surgery 2014;20(4):299-301
CountryChina
Language:Chinese
Abstract: Objective To study the effects of hydrogen-rich saline (HS) on the protection of hepatic injury induced by ischemia-reperfusion (I/R) in rats.Methods Male Sprague-Dawley rats (n =60) were randomly divided into three experimental groups:sham-operated group,I/R plus saline treatment group,and I/R plus hydrogen-rich saline treatment group.Reperfusion liver was conducted 180 mins after liver ischemia.Blood samples and liver tissues were collected.Result Serum ALT,AST levels,and MDA content,HMGB1,TNF-α,IL-1β and IL-6 levels in liver tissue were increased,but SOD and GSH activity were decreased significantly by I/R.Hydrogen-rich saline reduced oxidative stress and inflammatory reaction,and relieved morphological liver injury (P ＜ 0.01).Conclusion Hydrogen-rich saline attenuated I/R induced liver damage by reduction of oxidative injury and inflammatory reaction.