CHINET 2011 surveillance of antibiotic resistance in Stenotrophomonas malto-philia in China
- VernacularTitle:2011年中国 CHINET 嗜麦芽窄食单胞菌耐药性监测
- Author:
Xiaoman AI
;
Yunjian HU
;
Yunsong YU
;
Qing YANG
;
Yuxing NI
;
Jingyong SUN
;
Yingchun XU
;
Xiaojiang ZHANG
;
Ziyong SUN
;
Zhongju CHEN
;
Fu WANG
;
Demei ZHU
;
Fupin HU
;
Chao ZHUO
;
Danhong SU
;
Yuanhong XU
;
Jilu SHEN
;
Bin SHAN
;
Yan DU
;
Lianhua WEI
;
Ling WU
;
Zhaoxia ZHANG
;
Ping JI
;
Chuanqing WANG
;
Aimin WANG
;
Bei JIA
;
Wenxiang HUANG
;
Hong ZHANG
;
Jing KONG
- Publication Type:Journal Article
- Keywords:
Stenotrophomonas maltophilia;
glucose nonfermenter;
antimicrobial agent
- From:
Chinese Journal of Infection and Chemotherapy
2014;(2):94-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the resistance of clinical Stenotrophomonas maltophilia isolates from 15 hospitals in several regions of China during 2011.Methods Fifteen repre-sentative general hospitals were involved in this program. Bacterial susceptibility testing was carried out by means of a unified protocol using Kirby-Bauer method and MIC determi-nation.Results were analyzed according to CLSI 2011 break-points.Results Majority (93.3%) of the 1 889 clinical strains of S.maltophilia were isolated from inpatients.On-ly 6.7% of the isolates were from outpatients.About 62.9% of these S .maltophilia strains were isolated from old patients whose age was 60 years or older.Only 8.2% of the strains were from the patients younger than 18 years old.Sputum and re-spiratory tract secretion were the most common specimen source,accounting for 82.6%.Another 4.2% isolates were from blood,abdominal fluid and other sterile body fluids.The percentage of the S .maltophilia strain resistant to trimethoprim-sul-famethoxazole,levofloxacin and minocycline was 16.6%,10.0% and 1.8%,respectively.The strains resistant to cefopera-zone-sulbactam accounted for 19.0%.About 37.1% of the strains isolated from blood or sterile body fluids were resistant to trimethoprim-sulfamethoxazole,significantly higher than the strains from urine or wound specimens (P < 0.01).Conclusions S.maltophilia strains are mainly isolated from inpatients.The most common source is sputum and other respiratory speci-mens.Most of the patients with S.maltophilia isolate are 60 years of age or older.The S.maltophilia strains are constitu-tively resistant to several antibacterial agents,but showed relatively lower resistance to trimethoprim-sulfamethoxazole,levo-floxacin and minocycline.Cefoperazone-sulbactam is still active against these strains.The antimicrobial therapy targeting S. maltophilia infections should be selected cautiously according to the results of antimicrobial resistance surveillance.
