In vitro activity of a new antibacterial agent levornidazole against anaerobic bacteria
- VernacularTitle:抗菌新药左奥硝唑体外抗厌氧菌活性研究
- Author:
Jiali HU
;
Shi WU
;
Demei ZHU
;
Haihui HUANG
;
Yuancheng CHEN
;
Yang YANG
;
Yingyuan ZHANG
- Publication Type:Journal Article
- Keywords:
levornidazole;
anaerobe;
minimum inhibitory concentration;
resistance
- From:
Chinese Journal of Infection and Chemotherapy
2014;(2):100-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the in vitro antibacterial activity of levornidazole against 375 anaerobic isolates.Methods Agar dilution method was used to determine the minimum inhibitory concentrations (MICs)of levornidazole,3 comparators (metronidazole,ornidazole and dextrornidazole)against 375 anaerobic isolates.Results For anaerobic gram-negative and gram-positive bacilli,and anaerobic gram-positive cocci,levornidazole displayed activity similar to or slightly higher than that of met-ronidazole,ornidazole and dextrornidazole.Levornidazole showed good activity against B.fragilis,Bacteroides thetaiotaomi-cron ,Clostridium difficile ,Clostridium perfringens ,and Peptostreptococcus magnus .The MIC90 value of levornidazole a-gainst the above-mentioned anaerobes was 0.5,1,0.25,2 and 1 mg/L,respectively.However,levornidazole and the compa-rators had poor antibacterial activity against Veillonella spp.among anaerobic gram-negative cocci.Conclusions The in vitro anti-anaerobic activity of levornidazole is similar to or slightly higher than that of metronidazole, ornidazole and dex-trornidazole.Levornidazole has good activity against both gram-negative and gram-positive anaerobic bacilli,and gram-positive anaerobic cocci,suggesting its promising clinical use.
