A study on the efficacy ofβ-lactam antibiotics combined with macrolides in treatment of severe community-acquired pneumonia in children
10.3969/j.issn.1000-3606.2014.05.014
- VernacularTitle:β-内酰胺类与大环内酯类抗菌药物联合治疗重症社区获得性肺炎疗效回顾
- Author:
Jiafeng LI
;
Shibiao WANG
;
Guanghua LIU
;
Guanyu RUAN
;
Fanxiang ZENG
- Publication Type:Journal Article
- Keywords:
β-lactam antibiotics;
macrolides;
combination therapy;
community-acquired pneumonia
- From:
Journal of Clinical Pediatrics
2014;(5):453-455
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy ofβ-lactam combined with macrolides antibiotics in treatment of severe community-acquired pneumonia (CAP) in children. Methods Children with severe CAP on admission between 2012 February and 2012 April were divided into treatment group and control group. With the same symptom specific supportive treat-ment, the patients in the treatment group were treated with both cefmetazole and azithromycin, while the patients in the control group were treated with cefmetazole alone. The total effective rate, number of days of symptoms and signs disappeared and num-ber of days of hospitalization were observed. Results The total effective rate was 87.8%in the trearment group and 61.3%in the control group with significant difference (P<0.05). Compared with control group, the recovery time of temperature, time of pulmonary rale disappearing and cough retraction were reduced (P<0.05). As well as the number of days of hospitalization was decreased (P<0.05). Conclusions The treatment of severe CAP in children with combination of azithromycin and cefmetazole results in better curative effect. A combined medication ofβ-lactam and macrolides antibiotics may be rational and effective.
