The research progress of galactose-deficient IgA1 in the related kidney diseases
10.3969/j.issn.1000-3606.2014.05.023
- VernacularTitle:半乳糖缺乏的IgA1在相关肾脏疾病中的研究进展
- Author:
Yuheng ZHANG
;
Jin GAO
- Publication Type:Journal Article
- Keywords:
IgAnephropathy;
henoch-sch?nleinpurpuranephritis;
galactose-deficientIgA1;
henoch-sch?nleinpurpura
- From:
Journal of Clinical Pediatrics
2014;(5):489-491
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, IgA nephropathy and Henoch-Sch?nlein purpura nephritis attract more and more attention on their unclear pathogenesis, single diagnostic criteria, long duration and poor prognosis, etc. Research suggests that IgA nephropathy and purpura nephritis are IgA immune complex related diseases, and serum galactose-deficient is elevated in patients with these two dis-eases, which might become a noninvasive biomarker for the diagnosis, prognosis prediction and disease development monitoring for IgA nephropathy and purpura nephritis. Galactose-deficient IgA1 is reviewed for its discovery, structure, process, the possible patho-genic mechanism and its significance in details in this paper.
