Comparison of Surface Enhanced Raman Spectrum for Three Cephalosporins under Different pH Condi-tions
- VernacularTitle:不同酸碱条件下三种头孢菌素表面增强拉曼光谱的比较
- Author:
Juan ZHAO
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
Raman spectrum;
Surface enhanced Raman spectrum;
Different pH conditions;
Fingerprint characteristics;
Identify
- From:
China Pharmacist
2014;(4):546-549
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the Raman spectrum and the surface enhanced Raman spectrum ( SERS) of cefalexin, cefadroxil and cephradine, and analyze the surface enhanced Raman spectrum of the three compounds under different pH conditions. Methods:The Raman spectrum and the surface enhanced Raman spectrum of the three compounds under different pH conditions were detected and measured by a portable Raman spectroscopy. Results: The results showed that the three compounds could exhibit characteristic peak information in the surface enhanced Raman spectroscopy corresponding to that in the normal Raman spectrum, and the pH values had certain impact on the surface enhanced Raman spectrum of the three substances. Conclusion: Both the Raman spectrum and the surface enhanced Raman spectrum of cefalexin, cefadroxil and cephradine reflect certain fingerprint characteristics, and it is feasible to use Raman scattering method to identify the three cephalosporins.
