The clinical observation of Chinese medicine on TPOAb, TGAb of the patients with Hashimoto's thyroiditis
10.3760/cma.j.issn.1673-4246.2014.05.009
- VernacularTitle:自拟方对桥本甲状腺炎患者甲状腺球蛋白抗体、甲状腺过氧化物酶抗体的影响
- Author:
Ming DU
;
Hong WANG
;
Yingxin SHAO
- Publication Type:Journal Article
- Keywords:
Hashimoto's thyroiditis;
TCM syndrome differentiation and treatment;
Thyroid autoantibodies;
TPOAb;
TGAb
- From:
International Journal of Traditional Chinese Medicine
2014;(5):419-421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of the Chinese medicine on the patients’ thyroid autoantibodies TPOAb and TGAb of Hashimoto's thyroiditis. Methods 100 cases of Hashimoto's thyroiditis were randomly divided into group A and group B, with 50 cases in each group. Group A was given levothyroxine sodium(L-T4) to maintain thyroid function(FT3,FT4,TSH)in the normal range, at the same time Chinese medicines of soothing liver and strengthening spleen, nourishing the liver and kidney, activating blood and removing blood stasis were additionally added;while group B was taken L-T4 to maintain the thyroid function in the normal range. The levels of TPOAb, TGAb were determined before and after treatment in both groups. Results After the treatment, the level of TGAb and TPOAb[respectively(106.3±29.5)IU/ml,(871.5± 209.3)IU/ml] in group A were decreased compared with their previous level [respectively(385.5±76.6)IU/ml, (1621.5±399.2)IU/ml], the difference was statistically significant(t were 48.2、10.6,P<0.01). The level of TGAb and TPOAb [respectively(437.6±135.4)IU/ml,(1798.6±434.6)IU/ml] in group B were slightly increase than their previous level[respectively(383.9±105.8)IU/ml,(1633.2±396.5)IU/ml], with no significant difference. The levels of TPOAb and TGAb in group A had significant difference than those in group B after the treatment(t were 22.3、19.6,P<0.01). Conclusion TCM combined with L-T4 can reduce the level of thyroid autoantibodies of TPOAb and TGAb-in patients.
