Expressions and clinical significance of EGFR,CTEN and E-cad in non-small cell lung cancer
10.7652/jdyxb201403014
- VernacularTitle:EGFR、CTEN和E-cad在非小细胞肺癌中的表达及临床意义
- Author:
Xiaofeng GUO
;
Kunpeng YANG
;
Xinzheng CUI
;
Qingyong ZHANG
;
Ruilai LIU
;
Xiaoqing GE
;
Dong YAN
;
Jia CHANG
- Publication Type:Journal Article
- Keywords:
epidermal growth factor receptor;
COOH-terminus tensin-like molecule (CTEN);
epithelial cad-herin;
non-small cell lung cancer;
prognosis
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
2014;(3):346-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions and clinical significance of epidermal growth factor receptor (EGFR),COOH-terminus tensin-like molecule (CTEN)and epithelial cadherin (E-cad)in non-small cell lung cancer (NSCLC).Methods The expressions of EGFR,CTEN and E-cad in 36 cases of normal lung tissue and 82 cases of NSCLC tissues were observed with immunohistochemical SP method and their correlation with NSCLC invasion,metastasis and prognosis was analyzed.Results The positive rate of EGFR,CTEN and E-cad was 58.5% (48/82),69.5% (57/82)and 28.1% (23/82)in 82 cases of lung cancer,while 13.9% (5/36),0.0% (0/36)and 100% (36/36)in normal tissues;the differences were all significant (P<0.05).EGFR,CTEN and E-cad expressions in NSCLC tissues were significantly correlated with tumor differentiation,TNM stage and lymph node metastasis (P<0 .0 5 ).The expressions of EGFR and CTEN were correlated with each other in NSCLC (r=0 .5 3 0 , P<0.001),while the expressions of EGFR and CTEN were correlated with that of E-cad (r=0.499,P<0.001;r=0.333,P=0.001 ).Multivariate Cox regression analysis showed that CTEN expression in NSCLC was an independent prognostic factor (P<0.05 ).Conclusion EGFR,CTEN and E-cad may play a role in the development,invasion and metastasis of NSCLC and have some significance in predicting the prognosis of NSCLC.
