Expressions of CD147 and MMP-9 in laryngeal squamous cell carcinoma and their significance
10.7652/jdyxb201403023
- VernacularTitle:CD147和MMP-9在喉鳞癌中的表达及意义
- Author:
Desheng WANG
;
Yuanwei JIANG
;
Jianmin HUANG
;
Shuchun LIN
;
Haichun LAI
- Publication Type:Journal Article
- Keywords:
squamous cell carcinoma;
laryngeal neoplasm;
extracellular matrix metalloproteinase inducer (EMMPRIN);
matrix metalloproteinases-9 (MMP-9)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2014;(3):390-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of CD147 and matrix metalloproteinases-9 (MMP-9)in laryngeal squamous cell carcinoma (LSCC)tissue and their clinical significance.Methods The expressions of CD147 and MMP-9 were analyzed semi-quantitatively by immunohistochemical staining in LSCC and control group tissues.Results ① The positive rate of CD147 was 83.3% (30/36)in LSCC,which was higher than that in laryngeal polyp (33.3%,5/15)and in adjacent normal tissue (16.7%,6/36);it was related to histological grade, clinical stage and lymph node metastasis status (P<0 .0 5 ).② The positive rate of MMP-9 was 7 2 .2% (2 6/3 6 )in LSCC,which was higher than that in laryngeal polyp (13.3%,2/15)and in adjacent normal tissue (5.6%,2/36);it was related to histological grade,T stage,clinical stage and lymph node metastasis status (P<0.05).③ There was a positive correlation between the expressions of CD147 and MMP-9 in LSCC tissue (r=0.721,P=0.000). Conclusion The over-expressions of CD147 and MMP-9 in LSCC may contribute to the development and metastasis of LSCC.
