Comparison of drug eluting stent for treatment of intrastent restenosis and de novo lesion
10.3969/j.issn.1004-8812.2014.03.006
- VernacularTitle:冠状动脉支架内再狭窄病变与原发病变药物洗脱支架治疗的对比研究
- Author:
Weiwei ZHU
;
Chengjun GUO
;
Xianliang LIU
;
Hongyong SONG
;
Guanqiao DING
;
Lin ZHAO
- Publication Type:Journal Article
- Keywords:
Drug eluting stent;
De novo lesion;
In stent restenosis;
Target lesion revascularization
- From:
Chinese Journal of Interventional Cardiology
2014;(3):158-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective Compare the efifcacy and safety of drug eluting stent (DES) for treatment of in stent restenosis (ISR) and coronary de novo lesions. Methods Patients treated with DES for ISR and de novo lesions in Beijing Anzhen Hospital between October 2008 and December 2011 were followed up for 1 year. All lesions were divided into ISR and de novo group. Major adverse cardiovascular events (MACE) including all-cause death, myocardial infarction (MI) and clinical target lesion revascularization (TLR) were the primary endpoints. Results The study population consisted of 204 patients in the ISR group and 494 patients in the de novo group. Baseline clinical and angiographic parameters were comparable between the two groups. The rate of diabetic was higher in the ISR group than that in the de novo group (36.6%to 27.1%, P < 0.05). The diameter of coronary artery was smaller in the ISR group than that in the de novo group (2.72±0.36 to 3.08±0.54, P<0.01). The rate of TLR in the ISR group was higher than that in the de novo group (10.7%to 17.2%, P<0.05;14.2%to 21.1%, P<0.05),contributing to higher MACE in ISR group. Conclusions DES implantation is safe and effective for treatment of ISR lesions, but the rate of TLR is higher compared to treatment of de novo lesions.
