Anti-HLA and anti-MICA antibodies are positively correlated with transplanted kidney dysfunction
10.3760/cma.j.issn.0254-5101.2014.03.011
- VernacularTitle:抗 HLA 抗体和 MICA 抗体与移植肾存活的研究
- Author:
Baoxiang JIA
;
Junjie WU
;
Ye TIAN
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Anti-HLA antibody;
Anti-MICA antibody;
Transplanted kid-ney function
- From:Chinese Journal of Microbiology and Immunology
2014;(3):216-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between transplanted kidney dysfunction and oc-currence of the panel reactive antibody ( PRA, also referred as anti-HLA antibody ) and anti-Major-Histo-compatibility-Complex class Ⅰrelated chain A (MICA) antibody.Methods The tests for detecting PRA and anti-MICA antibody were performed on 679 renal transplant patients from December , 2009 to June, 2010 who received transplantation before 2008 in Beijing Friendship Hospital .Enzyme-Linked Immunosor-bent Assay ( ELISA) was used to detect anti-HLA antibody using LAT-1240 ( OneLambda Inc .) .MICA Ab-Scan Kit was adopted to detect anti-MICA antibody .Continuous observation of graft function was conducted . Results 108 out of 679 patients showed anti-HLA antibody and/or anti-MICA antibody positive results . Among them, 81 patients were positive only for anti-HLA antibody, 18 patients were positive only for anti-MICA antibody and other 9 patients showed anti-HLA and anti-MICA antibodies double positive .Among all of the kidney transplant patients with a failed or decreased renal function , 71 patients were positive for anti-HLA antibody;16 patients were positive for anti-MICA antibody;and other 9 patients were positive for both anti-HLA and anti-MICA antibodies .The results demonstrated that anti-HLA and anti-MICA antibodies af-fected the renal functions in patient with renal transplantation (χ2 =353.92, P <0.001).Conclusion Anti-HLA and MICA antibodies showed significant positive correlations with chronic allograft failure in the patients with renal transplantation .
