The effect of epicardial fat volume in patients with metabolic syndrome on insulin resistance and coronary heart disease
- VernacularTitle:代谢综合征患者心外膜脂肪体积对胰岛素抵抗及冠心病的影响
- Author:
Qiang WANG
;
Tao HANG
;
Yun XU
;
Xunming CHENG
;
Qigao ZHANG
;
Jianbing GONG
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Epicardial fat volume;
Insulin resistance;
Coronary heart disease
- From:
Journal of Medical Postgraduates
2014;(4):390-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective Epicardial fat volume ( EFV) was a risk factor for coronary heart disease ( CHD) , but there is little research regarding the relationship of EFV with insulin resistance ( IR) and CHD in patients with metabolic syndrome ( MS) .The aim of the article was to explore the effect of EFV in patients with MS on CHD and IR . Methods Patients with MS treated by percutane-ous coronary angiography ( CAG) in our hospital from February 2013 to August 2013 were recruited in this study .The data of height , weight, waist circumference(WC) and hip circumference(HP) were recorded.EFV were measured by MSCT.Fasting blood samples were collected for blood biochemical test . Results EFV in patients with MS was in positive relation with IR index (IRI)(r=0.335, P<0.001) and CHD (r=0.321, P<0.05), and the correlation still remained when the influences of WC and body mass index (BMI) were excluded.Logistic regression analysis showed that EFV was an independent risk factor for CHD (P<0.05), while linear regression analysis indicated EFV , BMI and LDL-C were the risk factors for IRI .ROC curves analysis proved EFV and BMI had diag-nosis value for IRI, and the areas under curve of EFV were 0.755 and 0.679 (P<0.05) respectively. Conclusion EFV is an in-dependent risk factor for CHD and IRI in patients with MS , and EFV has an advantage over BMI in the diagnosis value of IRI .
