The correlation between intraplaque neovascularization detected by contrast-enhanced ultrasound with the level of serum homocysteine
10.3760/cma.j.issn.1004-4477.2014.03.009
- VernacularTitle:超声造影评价动脉粥样硬化斑块内新生血管与血清同型半胱氨酸的关系
- Author:
Xiaoni CHANG
;
Jun FENG
;
Litao RUAN
;
Jing SHANG
;
Yanqiu YANG
;
Jian SUN
;
Yan SONG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Contrast media;
Atherosclerosis;
Neovascularization,pathologic;
Homocysteine
- From:
Chinese Journal of Ultrasonography
2014;23(3):206-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the degree of intraplaque neovascularization in carotid artery and the level of serum homocysteine.Methods Contrast-enhanced ultrasound were performed on 72 carotid atherosclerotic plaques of 48 patients.Contrast-enhancement within the plaque was categorizde as grade 1 to grade 3.The level of serum homocysteine were detected in the fasting state during the same period.Results According to the degree of contrast enhancement(grade 1 to 3),patients were divided into 3 groups.The more new vessels in plaque,the higher the level of homocysteine.The levels of homocysteine in three groups increased in turn.There were distinct differences among the three groups(F =18.49,P ＜0.05),and there was significant difference between every two groups (P ＜0.05).The linear correlation analysis showed that the level of homocysteine was positively correlated with the degree of carotid plaque enhancement (r =0.66,P ＜ 0.01).Conclusions Contrastenhanced ultrasonography could semi-quantitate new vessles in plaque.There was positive correlation between the degree of intraplaque neovascularization with the level of serum homocysteine.Combine with the level of serum homocysteine based on intraplaque neovascularization detected by contrast-enhanced ultrasound,the plaque stability could be more accurately evaluated.
