Effects of Sodium Ferulate treatment on the hypercoagulability of patients with plateau derived chronic cor pulmonale with acute ecacerbation phase at high altitude
10.3760/cma.j.issn.1008-6315.2014.04.016
- VernacularTitle:阿魏酸钠对高原慢性肺源性心脏病急性加重期患者高凝状态的影响
- Author:
Ying ZHANG
;
Qunke TANG
;
Chunping YUAN
;
Yuxiao WANG
- Publication Type:Journal Article
- Keywords:
Cor pulmonale;
Hypercoagulability;
Sodium Ferulate
- From:
Clinical Medicine of China
2014;30(4):387-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Sodium Ferulateon treating patients with plateau derived chronic cor pulmonale in acute ecacerbation phase at high altitude.Methods Forty-one cases with plateau derived chronic cor pulmonale were randomly divided into treatment group (22 cases) and control group (19 cases).All the patients in the two groups were given the same routine treatments including anti-infection,expectorant,balancing hydro-electrolytic discord,persistent inspiration of low-flow oxygen and inhalation by ultrasonic nebulization.Patients in treatment group were plus given the Sodium Ferulate at dose of 300 mg by intravenous drop once daily for 2 weeks.Hemorrheology,hepatic and renal function were examined.Results After treatment,the level of whole blood viscosity and plasma viscosity in treatment group were (4.91 ± 1.60) mPa · s and (1.56 ± 0.49) mPa · s,lower than that before treatment ((5.78 ± 1.65) mPa · s and (1.87 ± 0.65) mPa · s,P =0.042,0.041).There were no significant difference in the control group in terms of whole blood viscosity and plasma viscosity.There was not abnormal change of hepatic and renal function of two groups after treatment.Conclusion Sodium Ferulate therapy was effective to treatment of the plateau derived chronic cor pulmonale in acute ecacerbation phase.
