The correlation between serum epidermal growth factor, hepatocyte growth factor, and severity or prognosis of acute pancreatitis
10.3760/cma.j.issn.1008-1372.2014.03.025
- VernacularTitle:血清表皮生长因子、肝细胞生长因子与急性胰腺炎严重程度及预后的相关性
- Author:
Zhijuan LI
- Publication Type:Journal Article
- Keywords:
Epidermal growth factor/blood;
Hepatocyte growth factor/blood;
Pancreatitis;
Acute disease;
Severity of illness index;
Prognosis
- From:
Journal of Chinese Physician
2014;16(3):361-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum epidermal growth factor,hepatocyte growth factor and acute pancreatitis severity or prognosis,and to provide the basis for acute pancreatitis clinical diagnosis and treatment.Methods A total of 112 patients with acute pancreatitis (AP) were selected,and they were divided into mild acute pancreatitis (MAP) group (n =66) and severe acute pancreatitis (SAP) group (n =46) according to severity.The patients in two groups were treated with conventional therapy.The levels of serum epidermal growth factor (EGF) and hepatocyte growth factor (HGF) in two groups were observed.The correlation analysis was performed with acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score.The complications of patients in two groups were compared.Results The levels of serum EGF and HGF in MAP group and SAP group were significantly higher than those in control group,while they in SAP group were significantly higher than those in MAP group (P ＜ 0.01).The APACHE Ⅱ scores of MAP and SAP groups were (5.4 ± 1.6) ％ and (9 ±2.9) ％,and the APACHE Ⅱ score was positively related to serum EGF and HGF levels (P =0.00).The infection,abscess,necrosis,acute lung injury,or the incidence of ARDS in SAP Group were higher than that in MAP group (P ＜ 0.01).Conclusions AP severity and prognosis were related to patient's serum HGF and EGF levels.Therefore,early and timely monitoring changes of HGF,EGF,and HGF had a certain clinical value to assess condition and prognosis,and EGF had a strong tissue repair and regeneration functions,which might provide a new way to clinical treatment.
