Analysis of risk factors for diabetic nephropathy in patients with type-2 diabetes mellitus
10.3760/cma.j.issn.1008-1372.2014.03.019
- VernacularTitle:糖尿病肾病发生的相关因素分析
- Author:
Caihua PENG
;
Dan FAN
;
Jianhui CHEN
;
Kun LI
;
Wenping JIN
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Risk factors;
Chemokine CCL2/urine;
P-selectin/blood;
C-reactive protein/blood
- From:
Journal of Chinese Physician
2014;16(3):344-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of diabetic nephropathy.Methods According to the excretion rate of proteinuria,90 patients were divided into 3 groups:normal diabetic proteinuria group (DM),diabetic micro-proteinuria group (DN1),and clinical diabetic proteinuria group (DN2).We compared patients'ages,diabetic course,cholesterol,triglyceride,glycosylated hemoglobin,high density lipoprotein cholesterol (HDL),low density lipoprotein cholesterol (LDL),serum p-selectin,serum C-reactive protein,urinary monocyte chemotactic protein,and proteinuria excretion rate.Logistic regression analysis was used to analyze the relation between DN and various factors.Results Differences among these groups were statistically significant in type 2 diabetic course,HDL,LDL,p-selectin,C-reactive protein,glycosylated hemoglobin,and urinary monocyte chemotactic protein (P ＜ 0.05).Logistic regression analysis showed that diabetic course,LDL,C-reactive protein,p-selectin,and urinary monocyte chemotactic protein were independent risk factor (OR values were 2.238,1.062,6.723,1.166,and 1.046).Conclusions Occurrence and severity of DN had relationship with course of diabetes,microvascular lesions,and inflammatory reaction.Emphasis on monitoring and evaluation of the DN-related factors would contribute to the prevention and treatment of DN.
