The study of the correlation of the hyperuricemia with severity of coronary artery disease
- VernacularTitle:高尿酸血症与冠脉疾病严重程度的研究
- Author:
Zhiyong WU
- Publication Type:Journal Article
- Keywords:
Hyperuricemia;
Coronary artery disease;
Severity degree
- From:
Journal of Chinese Physician
2013;(z1):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assessed the relation of hyperuricemia with severity of coronary artery disease(CAD).Methods Three hundred and sixty patients having angiographic evidence of atherosclerosis (CAD + case group,n =360) compared to 150 patients with no luminal stenosis (n =90) and with ＜50％ luminal stenosis (n =60) at coronary angiography (CAD-control group,n =150),all patients be collected between Sep 2009 and Jun 2011 who visited our hospital.Results The mean age of the patients was (60 ± 10) years; the women had a greater prevalence of hypertension,diabetes mellitus,and hyperlipidemia compared to men,with statistical significance[respective as (30.1 ±4.5)kg/m2,165 (56.9％) 104(35.8％),207(71.3％) vs (27.3 ±3.9)kg/m2,118 (53.6％),62(28.2％),139 (63.2),allP ＜0.05),but serum levels of creatinine and uric acid significantly greater for men than women [respective as (119 ± 1.09) μmol/L,(453 ± 10.8) μmol/L vs (106 ±6.3) μ mol/L,(423 ± 12.6) μ mol/L,both P ＜ 0.01].Hyperuricemia was more likely associated with a trend toward higher vessel scores,indicating a more severe CAD (adjusted OR =1.52,P ＜ 0.05) in the whole population.A comparison of sex-specific values showed a significant association existed only in men.Conclusion Asymptomatic hyperuricemia may be associated with the presence and severity of angiographically-defined CAD in patients with suspicious symptoms for CAD.
