Association of GRM7 gene rs3749380 polymorphism with schizophrenia in Uygur Chinese population
10.3760/cma.j.issn.1674-6554.2014.03.004
- VernacularTitle:新疆维吾尔族人群中GRM7基因rs3749380多态性与精神分裂症的关联性研究
- Author:
Lili ZHANG
;
Qizhong YI
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
GRM7 gene;
Single nucleotide polymorphism;
Association study
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(3):203-206
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between GRM7 gene polymorphism and schizophrenia in the Uygur Chinese population.Methods rs3749380 at the GRM7 gene was selected for genotyping in a Uygur Chinese patients-control sample(case=360,control=384) by Taqman assays.The symptoms of schizophrenia were assessed by positive and negative syndrome scale(PANSS).SHEsis on line and SPSS 17.0 soft were used for calculating the data.Results For rs3749380 at GRM7 gene,the C allele frequency was 60.1％,and T allele frequency was 39.9％ in the patients.In the control,the C allele frequency was 58.6％,and T allele frequency was 41.4％.In the patients,the C/C genotype frequency was 38.6％,T/C genotype frequency was 43.1％,and T/T genotype frequency was 18.3％.In the controls,the C/C genotype frequency was 35.9％,T/C genotype frequency was 45.4％,and T/T genotype frequency was 18.7％.rs3749380 was not found to have genotypic or allelic association with schizophrenia(P＞0.05).And genotypic or allelic association with schizophrenia were not found between adolescent and adult cases,adolescent cases and controls or adult cases and controls(P＞0.05).The results showed rs3749380 genotypic or allelic was not association with schizophrenia in the different gender of the population (P＞ 0.05).The genotypes were not significantly correlated with symptoms of schizophrenia(P＞0.05).Conclusion There is no association of GRM7 gene rs3749380 polymorphism with the incidence of schizophrenia in Uygur Chinese.
