Resting state functional magnetic resonance imaging in patients with first-episode major depression disorder
10.3760/cma.j.issn.1674-6554.2014.04.014
- VernacularTitle:首发重性抑郁障碍静息态脑功能局部一致性及低频振幅研究
- Author:
Bing ZHAO
;
Guoqiang WEI
;
Liying HOU
;
Cheng XU
;
Kerang ZHANG
- Publication Type:Journal Article
- Keywords:
Depression disorder;
Function magnetic resonance imaging;
Restingstate;
Regional homogeneity;
Amplitude of low-frequency fluctuation;
Default mode network
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(4):334-337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the abnormally functional brain region in resting state in first-episode major depression disorder patients with function magnetic resonance imaging.Methods 51 patients diagnosed with first-episode major depression disorder according to DSM-Ⅳ and 50 gender-,age-,and education-matched healthy controls completed resting state fMRI scan.The severity of depression,and unpredicted homodynamic responses across the whole brain were analyzed using Hamilton depression scale,regional homogeneity and amplitude of low-frequency fluctuation,respectively.Results Compared with control group,the right medial frontal gyms (BA6,MNI:3,-3,63,K=34) and left medial frontal gyrus(BA9,MNI:-9,36,30,K=10) (P＜0.001,uncorrected) in the case group showed higher regional homogeneity,with statistical significance.Compared with control group,right medial frontal gyrus (BA6,MNI:3,-3,63,K =35) and right posterior cingulated gyrus (BA31,MNI:3,-36,36,K =11) (P＜ 0.001,uncorrected)in the case group showed higher amplitude of low-frequency fluctuation,with statistical significance.Conclusion First-episode major depression disorder patients in resting state had several abnormally functional brain regions,which might be related to the pathological mechanism of depression disorder.
