Correlation of serotonin 2A receptor and adenylate cyclase single gene polymorphisms and bipolar disorder
10.3760/cma.j.issn.1674-6554.2014.03.003
- VernacularTitle:5-羟色胺2A受体和腺苷酸环化酶相关基因位点单核苷酸多态性与双相障碍的关联分析
- Author:
Jianyue PANG
;
Jingjing SUI
;
Suxia CAO
;
Hengfen LI
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
5-HT2A receptor;
Adenylate cyclase;
Single nucleotide polymorphisms;
Biological marker
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(3):200-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether there is association between the polymorphisms of serotonin 2A receptor(5-HT2A) rs6311,rs6305 and adenylate cyclase rs2230739 with episode of bipolar disorder.Methods A case-control association study was done in this study,152 bipolar disorder patients (patients group),and 187 ageand gender-matched controls (control group) were recruited.Ligase detection reaction(LDR) was used to detect the distributive frequency of rs6311,rs6305 and rs2230739 of 152 bipolar disorder patients and 187 normal people.Results The 5-HT2A receptor rs6311 genotypes and alleles frequency distribution between patients group(11,12,22 genotypes:21％,61％,18％ ; 1,2 alleles:51％,49％) and control group(11,12,22 genotypes:44％,45％,11％ ; 1,2 alleles:66％,34％) showed statistically significance (P＜0.01).There were no differences of 5-HT2A receptor rs6305 genotypes and alleles between patients group and control group.The frequency of rs2230739 genotypes and alleles distribution between patients group (11,12,22 genotypes: 20％,43％,37％ ; 1,2 alleles: 42％,58％) and control group(11,12,22 genotypes: 17％,48％,35％ ; 1,2 alleles: 41％,59％) showed no significant difference(P=0.661,P=0.846).Conclusion The 5-HT2A receptor rs6311 polymorphism may be responsible for an increase in susceptibility to bipolar disorder,indicating that it maybe an marker to bipolar disorder.
