The effect of operation after neoadjuvant chemotherapy on gastric cancer patients with Ⅲ, Ⅳ grade
10.3760/cma.j.issn.1008-6706.2014.06.034
- VernacularTitle:Ⅲ、Ⅳ期胃癌新辅助化疗后再手术疗效观察
- Author:
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Chemotheapy,adjuvant
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(6):876-877
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of operation after neoadjuvant chemotherapy on gastric cancer patients with Ⅲ,Ⅳ grade.Methods 120 gastric cancer patients with Ⅲ,Ⅳ grade were selected.52 cases in the control group were given routine operation,68 cases in the observation group received neoadjuvant chemotherapy plus operation treatment.The operation resection rate,solid tumor progress assessment and postoperative recurrence rate in three months,six months and one year were observed.Results The radical resection of the observation group was 62.24％ (43/68),which was significantly higher than that of the control group 46.15％ (24/52) (x2 =5.81,P ＜0.05).The palliative resection and laparotomy of observation group were 20.59％ (14/68) and 16.18％ (11/68),which were significantly lower than those of the control group (x2 =4.04,4.92,all P ＜ 0.05).Tumor remission of the observation group was 61.76％ (43/68),which was significantly higher than that of the control group 50％ (26/52)(P ＜ 0.05).The tumor progress of the observation group was 17.65％ (12/68),which was significantly lower than that of the control group 28.85％ (15/52) (x2 =4.17,P ＜ 0.05).The tumor recurrence rates in 3 months and 6 months of the observation group were 10.29％ (7/68) and 17.65％ (12/68),which were significantly lower than those of the control group (x2 =4.61,P ＜ 0.05).Conclusion Neoadjuvant chemotherapy before operation can improve the operation resection rate,reduce the relapse rate,delay the recurrence and metastasis of gastric cancer,improve the prognosis of the patients.
