Effect of intensive insulin therapy on prognosis of patients with severe traumatic brain injury

VernacularTitle:强化胰岛素治疗对重型颅脑外伤患者预后的影响
Author: Hongwei YAO
Publication Type:Journal Article
Keywords: Traumatic brain injury; Intensive insulin therapy; Blood glucose
From: Chinese Journal of Primary Medicine and Pharmacy 2014;21(6):866-867
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of intensive insulin therapy on prognosis of patients with severe traumatic brain injury.Methods 130 patients with severe traumatic brain injury(GCS score 3-8) were randomly divided into the observation group (65 cases) and the control group (65 cases).The observation group received intensive insulin therapy,while the control group received conventional insulin therapy.The infection rate,hospital stay,in-hospital mortality and the 6-month mortality were observed.Results The infection rate of the observation group (32.4％) was significantly lower than that of the control group (46.7％) (x2 =1.946,P ＜ 0.05).The hospital stay of the observation group was significantly shorter than that of the control group (t =9.247,P ＜ 0.05).The inhospital mortality and the 6-month mortality were similar in the two groups(x2 =0.086,0.484,all P ＞ 0.05).The neurologic outcome according to Glasgow Outcome Score(GOS 4-5) at 6 months in the observation group was better than that in the control group(x2 =6.407,P ＜ 0.05).Conclusion Intensive insulin therapy can improve the prognosis of patients with severe traumatic brain injury.