Effect of atorvastatin combined with clopidogrel in the treatment of elderly patients with angina pectoris
10.3760/cma.j.issn.1008-6706.2014.06.014
- VernacularTitle:阿托伐他汀联合氯吡格雷治疗老年人心绞痛疗效观察
- Author:
Liubin LYU
;
Yaping SHI
;
Xiaofang WANG
- Publication Type:Journal Article
- Keywords:
Angina pectoris;
Atorvastatin;
Clopidogrel;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(6):831-833
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of atorvastatin combined with clopidogrel in the treatment of elderly patients with angina pectoris.Methods 90 elderly patients with angina pectoris were randomly divided into the observation group and control group,45 cases in each group.All patients were given conventional treatment and atorvastatin,the observation group was given clopidogrel based on this.The TC,TG,HDL-C,LDL-C,angina attack frequency,duration and adverse reactions,adverse cardiac events of two groups before and after treatment were compared,and the clinical effect was evaluated.Results The total effective rate of the observation group was 9 3.3 ％ (42/45),whichwassignificantlyhigherthan75.6％ (34/45) inthecontrolgroup (x2 =5.67,P ＜ 0.05).After treatment,the TC,TG,HDL-C,LDL-C of two groups were significantly improved than before treatment (t =5.34,4.78,4.56,4.92,4.31,3.92,4.11,4.62,all P ＜ 0.05),the improvement in the observation group was significantly better than that in the control group (t =4.20,4.08,3.98,4.03,all P ＜ 0.05).After treatment,the angina attack frequency and duration of two groups were significantly decreased compared with before treatment (t =6.22,5.78,4.12,4.02,all P ＜ 0.05),and the observation group decreased significantly than the control group(t =4.23,3.99,all P ＜ 0.05).3 cases of adverse reactions and 1 case of adverse cardiac events occurred in observation group,2 cases of adverse reaction and 3 cases of adverse cardiac events occurred in control group.Conclusion Atorvastatin combined with clopidogrel in the treatment of elderly patients with angina pectoris can regulate blood lipid and improve the symptoms of angina pectoris.
