Clinical efficacy of norepinephrine and dopamine in the treatment of shock and the impact on renal function

VernacularTitle:去甲肾上腺素与多巴胺治疗休克的临床疗效及对肾功能的影响比较
Author: Guangrui ZHAO ; Tuanzhou DUAN ; Yuan REN
Publication Type:Journal Article
Keywords: Shock; Blood urea nitrogen; Norepinephrine; Dopamine
From: Chinese Journal of Primary Medicine and Pharmacy 2014;21(6):882-883
CountryChina
Language:Chinese
Abstract: Objective To compare the effect of dopamine and norepinephrine in the treatment of shock and the effect on renal function.Methods 100 shock patients were randomly divided into norepinephrine group and dopamine group,50 cases in each group.On the basis of other anti-shock treatment,norepinephrine or dopamine was used in group A and group B.The mortality of the 7th day and urea nitrogen(BUN),creatinine values (CRE) 12h,72h after treatment were observed.Results There was no significant difference between two groups in the 7th day mortality (x2 =0.765,P ＞ 0.05).However,the proportion of arrhythmia in dopamine group was 34％,which was significantly higher than the norepinephrine group(16％) (x2 =3.84,P ＜ 0.05).After treatment,the BUN and CRE levels in both two groups recovered,the norepinephrine group recovered better than the dopamine group (P ＜ 0.05).Conclusion Norepinephrine and dopamine in the treatment of shock has similar clinical effect,but norepinephrine is more effective in the improvement of renal function compared with dopamine.