The effect of telmisartan on the plasma brain natriuretic peptide in patients with permanent cardiac pacing
10.3760/cma.j.issn.1673-4904.2014.13.003
- VernacularTitle:替米沙坦对永久性心脏起搏患者血浆脑利钠肽的影响
- Author:
Dan HE
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain;
Cardiac pacing,artificial;
Telmisartan
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(13):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of telmisartan on the plasma brain natriuretic peptide (BNP) in patients with permanent cardiac pacing.Methods According to the method of simple random numbers,106 patients with permanent cardiac pacing were randomly divided into study group and control group,with 53 cases in each group.All patients received implanted operation of permanent pacemaker.The study group was given telmisartan tablets,1 time a day,1 tablet each time,until the end of follow-up.The control group was given valsartan.The plasma BNP was measured by the immunofluorescent assay before administration and at the end of follow-up.In addition,left ventricular ejection fraction (LVEF) and cardiac index (CI) was determined by echocardiography.Results The plasma BNP in two groups was lower than 100 ng/L before administration.At the end of follow-up,the plasma BNP changed slightly in study group,but increased in control group,and the plasma BNP in control group was higher than that in study group [(105.67 ± 15.64) ng/L vs.(73.23 ± 10.56) ng/L],and there was significant difference (P ＜ 0.05).LVEF and CI was stable within the normal range before administration and at the end of follow-up in study group [(58 ± 4)％ vs.(59 ± 5)％,(3.58 ± 0.32) L/(min· m2) vs.(3.56 ± 0.26) L/(min· m2)].LVEF and CI at the end of follow-up in control group was decreased compared with that before administration[(49 ± 3)％ vs.(56 ± 3)％,(2.97 ± 0.26) L/(min· m2) vs.(3.62 ± 0.29) L/(min· m2)],which was lower than that in study group[(49 ± 3)％ vs.(59 ±5)％,(2.97 ±0.26) L/(min·m2) vs.(3.56 ±0.26) L/(min·m2)],and there was significant difference(P ＜ 0.05).Conclusions Telmisartan can delay the increase of the plasma BNP in patients with permanent cardiac pacing,delay the onset of symptoms of heart failure,and improve the quality of life.So early administration of telmisartan is recommended for the patients with permanent cardiac pacing.
