The analysis of the blood fatty in different genotypes of matrix metalloproteinases in the carotid atherosclerosis patients with essential hypertension
10.3760/cma.j.issn.1673-4904.2014.10.016
- VernacularTitle:原发性高血压伴发颈动脉粥样硬化患者基质金属蛋白酶不同基因型血脂分析
- Author:
Xinjuan XU
;
Yanping MA
;
Rong REN
;
Fang ZHAO
;
Junshi ZHANG
;
Guangmei HU
- Publication Type:Journal Article
- Keywords:
Matrix Metalloproteinases;
Genes;
Hypertension;
Atherosclerosis
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(10):46-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the blood fatty levels in different genotypes of matrix metalloproteinases (MMP) and the carotid atherosclerosis (CAS) in patients with essential hypertension (EH).Methods Four hundred and eighty-eight cases of Han and Uygur in patients with EH were selected,and MMP-2-735 C/T and MMP-3-1171 5A/6A polymorphism was measured by polymerase chain reactionrestriction fragment length polymorphism.They were divided into two groups:EH with CAS group (CAS group,293 cases,Han 171 cases,Uygur 122 cases) and EH without CAS group (NS group,195 cases,Han 105 cases,Uygur 90 cases).Blood fatty factors were analyzed according to the different MMP genotypes.Results According to MMP-2 genotypes,in Hart CAS group,the low density lipoprotein cholesterol (LDL-C) levels in MMP-2 CT+TT genotypes were significantly higher than those in CC genotype(P ＜ 0.05),and high density lipoprotein cholesterol levels were significantly lower than those in CC genotype(P ＜ 0.05); In Uygur CAS group,the triglyceride levels in MMP-2 CT+TT genotypes were significantly higher than those in CC genotype(P ＜ 0.05).According to MMP-3 genotypes in Han NS group,the total cholesterol and LDL-C levels in 6A/6A genotype were significantly higher than those in 5A/5A+5A/6A genotypes (P ＜ 0.05).Conclusion The blood fatty levels are different in patients with different MMP genotypes,which may probably influence the CAS.
