High-dose methylprednisolone effect on infantile spasms
10.3760/cma.j.issn.1673-4912.2014.04.008
- VernacularTitle:大剂量甲泼尼龙冲击治疗婴儿痉挛症的临床分析
- Author:
Qinghua YANG
;
Tianming JIA
;
Liping ZOU
;
Xiaoli ZHANG
- Publication Type:Journal Article
- Keywords:
Infant spasms;
Methylprednisolone;
Antiepileptic drugs;
Treatment effect
- From:
Chinese Pediatric Emergency Medicine
2014;21(4):225-227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss high dose methylprednisolone therapy in infantile spasm.Methods Sixty-six children with infantile spasm of the Third Affiliated Hospital of Zhengzhou University from Nov 2002 to Nov 2012,adopted intravenous methylprednisolone with 20 mg/(kg· d) for 3 to 5 days continuously,then changed to oral prednisone with 1 ～ 2 mg/(kg.d),4 ～ 8 weeks after drug withdrawal.The total course of 8 ～ 12 weeks of clinical curative effect was retrospectively studied.Results (1) Of 66 cases,51 cases were effective,total effective rate was 77.2％ ;28 cases achieved complete response,complete response rate was 42.4％.(2) The onset age had no influence on curative effect (P ＞ 0.05).(3) The beginning ages of the patients to use methylprednisolone therapy had no effect on curative effect (P ＞0.05).(4) Course of curative effect:23 cases within 2 months,the effective rate was 91.3％,43 cases more than 2 months,the effective rate was 69.7％.Difference of effective rate between the two groups had statistical significance (x2 =3.958,P ＜ 0.05).(5) Etiology of curative effect:50 cases of symptomatic,the effective rate was 78.0％,16 cases of cryptogenic,the effective rate was 75.0％ ;compared two groups,the effective rates had no statistical significance(x2 =0.008 7,P ＞ 0.05).(6) Long-term follow-up of 41 cases,14 cases had complete remission (34.2％),29 cases was effective(70.7％),3 cases had a recurrence (10.3％).Conclusion Application of methylprednisolone in the treatment for infantile spasm is simple,the recent control is effective,and it has a less adverse effect.The curative effect is related to the course,the shorter the duration,the better curative effect;and the long-term effect is good,the recurrence rate is low,the method can be recommended in clinical application.
