Basis of molecular pathology in colorectal carcinogenesis
10.3760/cma.j.issn.1673-422X.2014.05.011
- VernacularTitle:结直肠癌发生的分子病理学基础
- Author:
Weiguo JIANG
;
Youguang HUANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Genes;
Mutation;
Methylation
- From:
Journal of International Oncology
2014;41(5):353-357
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal carcinogenesis is the result of accumulation of genetic and epigenetic alters.Gene mutations and changes in DNA methylation patterns,resulted from genomic instability,are the main molecular events in colorectal cancer.Identification of key mutations and methylation phenotypes in genes leading to colorectal cancer progression,and molecular pathology classification and diagnosis are likely to be the prerequisites for individualized and targeted treatment.
