Molecular targeted therapy of tumor hypoxia
10.3760/cma.j.issn.1673-422X.2014.05.003
- VernacularTitle:肿瘤乏氧分子靶向治疗
- Author:
Shanshan LI
;
Ligang XING
;
Xiaorong SUN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Anoxia;
Molecular targeted therapy
- From:
Journal of International Oncology
2014;41(5):327-331
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia is an inherent feature of the majority of solid tumors,which can increase the resistance of tumor cells to radiotherapy and chemotherapy,promote tumor angiogenesis and lead to poor prognosis.Therefore,targeting the hypoxic tumor cells has become a spot in cancer therapy.Bioreduction drugs can be activated by a specific reduction to become cytotoxic metabolites,thus killing hypoxic tumor cells,while small molecular targeting inhibitors can selectively act on the key point of hypoxia pathway.They have paved a new way for hypoxia targeted therapy.
