Research progress of the abnormal expression of Sox genes in breast cancer
10.3760/cma.j.issn.1673-4203.2014.03.016
- VernacularTitle:Sox基因的异常表达与乳腺癌研究的进展
- Author:
Jing SHI
;
Jiaxin ZHANG
- Publication Type:Journal Article
- Keywords:
Genes;
Breast neoplasms;
Gene expression;
Sox2;
Sox4;
Sox7;
Sox17
- From:
International Journal of Surgery
2014;41(3):197-200
- CountryChina
- Language:Chinese
-
Abstract:
Sox gene family is composed of a class of SRY gene,encoding a series of transcription factors.In the ontogeny,sox genes involved in a variety of development,such as sex determination and differentiation,neural development,cartilage formation.In recent years,researchers found that the abnormal expression of sox gene was related with the development of breast cancer,such as,the overexpression of Sox2 and Sox4 was related with breast cancer; Sox7 and Sox17 in breast cancer could act as tumor suppressor gene,the downregulation of which could activate Wnt/β-catenin signaling pathway.
