Endoplasmic reticulum stress and cognitive impairment
10.3760/cma.j.issn.1673-4165.2014.03.013
- VernacularTitle:内质网应激与认知损害
- Author:
Yining XIAO
;
Peiyuan LYU
- Publication Type:Journal Article
- Keywords:
Stress,Physiological;
Endoplasmic Reticulum;
Cognition Disorders
- From:
International Journal of Cerebrovascular Diseases
2014;22(3):222-226
- CountryChina
- Language:Chinese
-
Abstract:
In eukaryotic cells,endoplasmic reticulum (ER) is a locus where the proteins are modified,folded and the calcium is stored.When the harmful factors,such as ischemia/hypoxia,lack of nutrients,viral infections,and toxins cause the homeostasis damage in the endoplasmic reticulum,the accumulation of unfolded or misfolded proteins and the calcium imbalance may result in endoplasmic reticulum stress (ERS).ERS induces the expression of endoplasmic reticulum chaperones and endoplasmic reticulum associated degradation components,and reduces the load of the endoplasmic retlculum by temporarily reducing protein synthesis.Studies have shown that many diseases that can induce cognitive impairment are all associated with ERS.
