Effect of different military stress loads and modes on level of stress hormones in rats
10.7644/j.issn.1674-9960.2014.04.011
- VernacularTitle:不同应激模式下血清中重要应激激素的变化规律
- Author:
Xinxing WANG
;
Xiujie GAO
;
Jingbo GONG
;
Zhusong MEI
;
Weili LIU
;
Jing MA
;
Yun ZHAO
;
Lingjia QIAN
- Publication Type:Journal Article
- Keywords:
military stress load;
military stress pattern;
hormone
- From:
Military Medical Sciences
2014;(4):277-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematially observe the different patterns and leves of military stress on modified multitle-platform method the level of stress-related hormones in rats .Methods A sleep deprivation model was established by water environment modified multiple-platform method(MMPM).A restraint stress model was established by self-made bondage cage.Chronic unpredictable mild stress ( CUMS) model was established by action control , cage damp, cage tilt, night lightening, water and food fasting , empty bottles stimulation and group feeding methods .Cortisol, catecholamines and 5-HT levels were detected to observe the different military stress loads and modes on the level of stress hormones .Results The level of serum cortisol increased significantly ( P <0.05 ) after 5 days of sleep deprivation .The level of serum catecholamines increased significantly (P<0.05) after 1 day of sleep deprivation.The cortisol concentration increased and the level of 5-HT decreased in serum after 4 weeks CUMS.The level of catecholamines increased significantly (P<0.05) after 2-8 weeks of CUMS, increased significantly (P<0.05) after 1 week of restraint stress , and returned to normal after 3-4 weeks of restraint stress .The level of serum cortisol increased significantly after 3 -4 weeks of restraint stress . Conclusion Cortisol levels gradually increased with the level of stress in different military stress modes , which can serve as an index to evaluate the level of different stress modes .
